directions. Having certain tendencies, he must move along their lines to the limit of their potentialities."
John Steinbeck - Log from the Sea of Cortez
Saturday, March 6, 2010
Sleep well
No need for concern - no candiru in Sumter County streams. But then again, there are those madtoms.
Almost dinosaur
Water, water, everywhere...
Greatly appreciate the efforts, though, and the access to some great sites. A lot of the people that we talk to seem to be afraid that we're going to find a panda riding a black rhino.
Friday, March 5, 2010
Forever young?
The cover story of this week's Science details the work of a group of scientists at UCSD's School of Medicine in which they have identified a protein that may play a major role in the inhibition of aging in fruit flies. The protein, known as sestrin, is also found in humans and seems to have a similar biochemical function. Sestrins have been known for some time, and are produced in abundance by cells under stress. Their function, however, had remained a mystery. The UCSD group demonstrates that sestrins serve to activate of AMP-dependent protein kinase (AMPK), and inhibit the Target of Rapamycin (TOR). These two protein kinases play a major role in the pathway that regulates the aging process in a wide range of organisms including the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and, yes, you.
The two kinases have opposite actions - AMPK is activated by a lowering of caloric intake, while increased intake activates TOR. It's been shown that drugs that stimulate AMPK or inhibit TOR can slow down aging in model organisms. Our understanding of sestrin function has been impeded by the fact that there are three different sestrin-encoding genes in mammals. In fruit flies, however, a single gene codes for the protein. When the researchers inactivated this gene, they saw decreased activity of AMPK and increased activity of TOR. The result was the development of a number of age-related pathologies.
The potential significance is huge - the researchers hope that sestrin or analogues may eventually be used to slow down the aging process and treat many of the degenerative diseases associated with aging. Good luck on that. Wish they had found this thirty years ago.
Thursday, March 4, 2010
Kind of saw this coming
And one back from the dead...
Return of the Asteroid
Wednesday, March 3, 2010
Not easy...
Amphibians have had it tough lately. They're landslide winners of the Most Endangered Vertebrate Class Sweepstakes, often referred to as the "canary in the coal mine" with regard to impending environmental threats. It's important to remember that, while coal mine canaries might serve a noble cause, they're still ex-canaries. So, why are so many amphibians staring down the barrel of extinction? Oh, a whole host of issues, ranging from sensitivity to pollutants, fungal diseases, habitat loss, and increased UV radiation.
Well, add this one. The pesticide atrazine, about 80,000 tons of which are applied annually in the U.S., chemically castrates 75% of male frogs and turns about 10% into females. This from the lab of UC-Berkeley's Tyrone Hayes, where frogs were raised for three years in water containing 2.5 ppb of atrazine.
The European Union has banned the use of atrazine, and several U.S. states are considering the same. As a result of many recent studies pointing toward the ill effects of the pesticide, the EPA is reviewing existing regulations. Only question - is it too little, too late for The Green One?
Tuesday, March 2, 2010
Busy season
Put together some musical numbers for the banquet. Here you go...